KMID : 1100920210420040310
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Korean Journal of Family Medicine 2021 Volume.42 No. 4 p.310 ~ p.316
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Short- and Long-Term Exposure to Particulate Matter and Pulse Wave Velocity
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Park Young-Jun
Cho Yu-Jin Kwak Jin-Seul Lim Youn-Hee Park Min-Seon
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Abstract
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Background: In hemodialysis patients, brachial-ankle pulse wave velocity (baPWV) levels are affected by particulate matter with an aerodynamic diameter of 10 ¥ìm or less (PM10). We conducted this study to determine whether there is an association between short- and long-term PM10 exposure and baPWV in apparently healthy adults aged 40 years and older.
Methods: A total of 1,628 subjects who underwent health examinations between 2006 and 2009 were included in the study. On the basis of the day of medical screening, the 1?3-day and 365-day moving averages of PM10 concentrations were used to evaluate the association between short- and long-term exposure to PM10 and high baPWV (¡Ãthe third quartile of baPWV, 1,534 cm/s) using logistic regression models. Additional subgroup analyses were conducted according to age, sex, obesity (body mass index ¡Ã25.0 kg/m2), and comorbidities such as metabolic syndrome.
Results: No statistically significant associations were identified between short-term and long-term exposure to PM10 and baPWV in any of the subjects and subgroups. A 10-¥ìg/m3 increase in the 2-day moving average of PM10 exposure was marginally associated with high baPWV in non-obese subjects (odds ratio, 1.059; P=0.058). This association in non-obese subjects was significantly different from that in obese subjects (P=0.038).
Conclusion: This study did not show statistically significant associations between short-term and long-term exposure to PM10 and baPWV in apparently healthy subjects. With short-term exposure to PM10, non-obese subjects showed a marginally unfavorable association with baPWV. Further studies are necessary to validate and elucidate the mechanism underlying the effect of PM10 on baPWV.
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KEYWORD
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Vascular Stiffness, Air Pollution, Brachial-Ankle Pulse Wave Velocity, Particulate Matter
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